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	Provedor de dados ArchiMer (5) Autor Biard, J (2) Geiger, Marie (2) Mondeguer, Florence (2) Pouchus, Y (2) Amiard, Jean-claude (1) Bissett, J (1) Blanchet, Estelle (1) Dalgalarrondo, M (1) Du Pont, T. Robiou (1) Frisvad, J. C. (1) Grovel, Olivier (1) Guitton, Yann (1) Hess, Philipp (1) Kerzaon, I. (1) Mohamed Benkada, M (1) Montagu, M (1) Montagu, Monique (1) Petit, Karina (1) Poirier, Laurence (1) Pouchus, Y. F. (1) Mais... Palavra-chave Marine fungi (5) Cytotoxicity (2) Penicillium (2) Acide okadaïque (1) Activité antibactérienne (1) Antibacterial activity (1) Antifungal (1) Azadinium spinosum (1) Azaspiracid (1) Azaspiracide (1) Beauveria brongniartii (1) Bivalve bioassay (1) Cytotoxicité (1) Dereplication (1) Dinoflagellates (1) Dinoflagellés (1) Diptera larvae (1) Electrospray ionisation multiple stage mass spectrometry ion trap (ESI MSn IT) (1) Embryotoxicity (1) Griseofulvin (1) Mais... Tipo do documento Text (5) Ano 2013 (2) 2007 (1) 2006 (1) 2004 (1) País France (5) Idioma Inglês (4) Francês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Cytotoxicity and mycotoxin production of shellfish-derived Penicillium spp., a risk for shellfish consumers ArchiMer Geiger, Marie; Guitton, Yann; Vansteelandt, M.; Kerzaon, I.; Blanchet, Estelle; Du Pont, T. Robiou; Frisvad, J. C.; Hess, Philipp; Pouchus, Y. F.; Grovel, Olivier. In order to assess the putative toxigenic risk associated with the presence of fungal strains in shellfish-farming areas, Penicillium strains were isolated from bivalve molluscs and from the surrounding environment, and the influence of the sample origin on the cytotoxicity of the extracts was evaluated. Extracts obtained from shellfish-derived Penicillia exhibited higher cytotoxicity than the others. Ten of these strains were grown on various media including a medium based on mussel extract (Mytilus edulis), mussel flesh-based medium (MES), to study the influence of the mussel flesh on the production of cytotoxic compounds. The MES host-derived medium was created substituting the yeast extract of YES medium by an aqueous extract of mussel tissues, with... Tipo: Text Palavras-chave: Cytotoxicity; Dereplication; Marine fungi; Mass spectrometry; Penicillium; Shellfish. Ano: 2013 URL: http://archimer.ifremer.fr/doc/00160/27166/25523.pdf Detection of griseofulvin in a marine strain of Penicillium waksmanii by ion trap mass spectrometry ArchiMer Petit, Karina; Mondeguer, Florence; Roquebert, M; Biard, J; Pouchus, Y. A marine strain of Penicillium waksmanii Zaleski was isolated from a sample of seawater from shellfish-farming area in the Loire estuary (France). The in vitro marine culture showed an important antifungal activity. Bioassay-guided fractionation was used to purify the crude extract. Dereplication by electrospray-ion trap/mass spectrometry (ESI-IT/MS) afforded the identification of the antifungal compound, after a semi-purification consisting of two stages. A comparison of the ionic composition between the active and the non-active fractions allowed the detection of a monocharged ion at m/z 353 containing a chlorine atom, which could be attributed to the antifungal griseofulvin [C17H17ClO6+H](+). Multi-stage fragmentation (MSn) confirmed the identity of the... Tipo: Text Palavras-chave: Mass spectrometry ESI IT/MS; Griseofulvin; Antifungal; Marine fungi; Penicillium waksmanii. Ano: 2004 URL: http://archimer.ifremer.fr/doc/2004/publication-673.pdf Évaluation d’une suite de bio-essais pour la détection et l’étude de composés lipophiles de micro-organismes marins issus de mollusques bivalves et de leur environnement ArchiMer Geiger, Marie. The context of this study was the assessment of the safety of edible bivalve molluscs. Bivalve can indeed accumulate high concentrations of phycotoxins into their hepatopancreas, potentially leading to human intoxication outbreaks after consumption of such contaminated bivalves. In order to ensure the protection of shellfish consumers, regulated toxins are monitored using physico-chemical techniques. In parallel, emerging toxins, that can be putatively produced by microalgae or marine fungi, are monitored using the intraperitoneal mouse bioassay. However, this bioassay suffers ethical and methodological drawbacks. Thus, the objective of this work was to assess the ability of a bioassay suite to detect lipophilic toxins. This suite was composed of three... Tipo: Text Palavras-chave: Cytotoxicité; Larves de diptères; Activité antibactérienne; Toxines lipophiles; Micro-algues; Dinoflagellés; Micromycètes; Penicillium; Acide okadaïque; Azaspiracide; Pinnatoxine G; Vulcanodinium rugosum; Prorocentrum lima; Azadinium spinosum; Beauveria brongniartii; Cytotoxicity; Diptera larvae; Antibacterial activity; Lipophilic toxins; Microalgae; Dinoflagellates; Marine fungi; Penicillium; Okadaic acid; Azaspiracid; Pinnatoxin G; Vulcanodinium rugosum; Azadinium spinosum; Prorocentrum lima; Beauveria brongniartii. Ano: 2013 URL: http://archimer.ifremer.fr/doc/00183/29426/27787.pdf New short peptaibols from a marine Trichoderma strain ArchiMer Mohamed Benkada, M; Montagu, M; Biard, J; Mondeguer, Florence; Verite, P; Dalgalarrondo, M; Bissett, J; Pouchus, Y. The production of peptaibols by a marine-related Trichoderma longibrachiatum strain was studied using electrospray ionisation multiple-stage ion trap mass spectrometry (ESI-MSn-IT) and gas chromatography/electron impact mass spectrometry (GC/EI-MS). Two major groups of peptaibols were identified, those with long sequences (20 amino acids) and others with short sequences (11 amino acids). This paper describes the methodology used to establish the sequences of short peptaibols in a mixture without previous individual separation. Nine peptaibols were identified. Among them, eight are new, namely as trichobrachin A I-IV (Aib(9)-Pro(10) sequence) and as trichobrachin B I-IV (Val(9)-Pro(10) sequence). Original Pro(6)-Val(7) and Val(9)-Pro(10) sequences have to... Tipo: Text Palavras-chave: Trichoderma longibrachiatum; Marine fungi; Marine products; Electrospray ionisation multiple stage mass spectrometry ion trap (ESI MSn IT); Short peptaibols. Ano: 2006 URL: http://archimer.ifremer.fr/doc/2006/publication-1550.pdf Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos ArchiMer Poirier, Laurence; Quiniou, Francoise; Ruiz, Nicolas; Montagu, Monique; Amiard, Jean-claude; Pouchus, Yves François. Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were performed to assess acute toxicity of alamethicin and different groups of peptaibols produced by a Trichoderma longibrachiatum strain isolated from marine environment. C gigas embryos appeared very sensitive to all the metabolites examined with higher toxic effects for long-sequence peptides (EC50 ranging from 10 to 64nM). D-shaped larvae with mantle abnormality were particularly noticed when peptaibol concentrations increased. Disturbances of embryogenesis were also observed following... Tipo: Text Palavras-chave: Risk assessment; Embryotoxicity; Bivalve bioassay; Mycotoxins; Marine fungi. Ano: 2007 URL: http://archimer.ifremer.fr/doc/2007/publication-2680.pdf Registros recuperados: 5 Primeira ... 1 ... Última

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